Risk Factors for Uterine (Endometrial) Cancer
Medical Conditions and Treatments
- Diabetes mellitus—the relationship between diabetes and increased uterine cancer risk is not clearly understood, but may also be related to obesity.
- Hereditary nonpolyposis colorectal cancer—This is a rare, hereditary condition in which many family members develop bowel tumors and other tumors. The lifetime risk of developing uterine cancer is close to 50% in women in these families.
- Tamoxifen —a drug used in the treatment and prevention of breast cancer.
- Patients with polycystic ovary syndrome and granulose theca cell tumors of the ovary—the increased risk of uterine cancer is likely a result of increased estrogen levels.
- Menopausal use of estrogen without progesterone—studies show an increased risk when estrogen is taken alone, without progesterone, for relief of menopause symptoms.
- Radiation therapy to the pelvic area—previous cancer treatment with radiation may increase your risk of uterine cancer.
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What are the risk factors for endometrial cancer? American Cancer Society website. Available at: http://www.cancer.org/docroot/CRI/content/CRI%5F2%5F4%5F2X%5FWhat%5Fare%5Fthe%5Frisk%5Ffactors%5Ffor%5Fendometrial%5Fcancer.asp . Updated July 2008. Accessed August 31, 2009.
8/31/2009 DynaMed Systematic Literature Surveillance DynaMed's Systematic Literature Surveillance : Thomas CC, Wingo PA, Dolan MS, Lee NC, Richardson LC. Endometrial cancer risk among younger, overweight women. Obstet Gynecol. 2009;114:22-27.
- Reviewer: Igor Puzanov, MD
- Review Date: 09/2011
- Update Date: 09/19/2011