(Cancer of the Adrenal Cortex; Adrenal Cortical Carcinoma; Adrenal Cancer)
|Anatomy of the Adrenal Glands|
|Copyright © Nucleus Medical Media, Inc.|
- Sex: female
- Children under 5 years old
- Adults between 40 and 50 years old
- A genetic defect may cause adrenocortical cancer in some children, but the majority of cases are nonhereditary
- Cushings syndrome
- Conns syndrome
- A mixed Cushings syndrome and virilization
- In young children with functional tumors that release sex hormones, these tumors may cause early onset of puberty
- Blood tests
- Urine tests
- CT scan
- MRI scan
- Positron emission tomography (PET)/CT scan
- Adrenal angiography and/or venography
Adrenalectomy Surgery to Remove the Tumor
- Mitotane is the drug most often used for this type of cancer, especially for hormonally active tumors. It blocks hormone production by the adrenal gland. It also destroys adrenal cancer cells. This drug does have serious side effects.
- Other hormone blocking drugs may be given to control the symptoms of excess hormones.
- Research of new drug and radiation therapies are under way. This includes gene and immunotherapy.
American Cancer Society http://www.cancer.org
National Cancer Institute http://www.cancer.gov
BC Cancer Agency http://www.bccancer.bc.ca
Canadian Cancer Society http://www.cancer.ca
Abiven G, Coste J, et al. Clinical and biological features in the prognosis of adrenocortical cancer: poor outcome of cortisol-secreting tumors in a series of 202 consecutive patients. J Clin Endo & Metab. 2006;91:2650-2655.
Adrenal cortical carcinoma. EBSCO DynaMed website. Available at: https://dynamed.ebscohost.com/about/about-us. Updated May 15, 2013. Accessed June 28, 2013.
Adrenocortical carcinoma. National Cancer Institute website. Available at: http://www.cancer.gov/cancertopics/types/adrenocortical. Accessed June 28, 2013.
Adrenocortical carcinoma: treatment statement for health professionals. National Cancer Institute website. Available at: http://www.meb.uni-bonn.de/cancer.gov/CDR0000062907.html. Updated November 15, 2012. Accessed June 28, 2013.
Allolio B, Fassnacht M. Adrencortical carcinoma: clinical update. J Clin Endocrinol Metab. 2006;91:2027-37.
Detailed guide: adrenal cortical cancer. American Cancer Society website. Available at: http://www.cancer.org/cancer/adrenalcorticalcancer/index. Accessed October 31, 2012.
Kirschner LS. Review: emerging treatment strategies for adrnocortical carcinoma: a new hope. J Clin Endocinol Metab. 2006;91:14-21.
Van Ditzhuijsen cI, van de Weijer R, Haak HR: Adrenocortical carcinoma. Neth J Med. 2007;65:55-60.
- Reviewer: Mohei Abouzied, MD; Michael Woods, MD
- Review Date: 06/2013
- Update Date: 06/28/2013