Variant Creutzfeldt-Jakob Disease
(Human Mad Cow Disease; vCJD)
|The Nervous System|
|Copyright © Nucleus Medical Media, Inc.|
- Eating beef from infected cows
- Receiving a blood transfusion from someone who had the disease
- Early phase (0 to 6 months)— psychiatric symptoms, such as depression , anxiety , withdrawal, memory problems, and difficulty pronouncing words
- Middle phase—neurologic symptoms predominate, such as abnormal gait, problems with coordination, muscle jerks and stiffness, and impaired speech
- Late phase—mute, immobility
- Blood tests
- Electroencephalogram (EEG) to record the electical activity of the brain
- Cerebrospinal fluid analysis
- Brain biopsy
- Tonsillar biopsy
Creutzfeldt-Jakob Disease Foundation, Inc. http://www.cjdfoundation.org
National Institute of Neurological Disorders and Stroke http://www.ninds.nih.gov
Health Canada http://www.hc-sc.gc.ca
Public Health Agency of Canada http://www.phac-aspc.gc.ca
Brown K, Mastrianni JA. The prion diseases. J Geriatr Psychiatry Neurol . 2010;23:277-98.
Creutzfeldt-Jakob disease. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed/what.php . Updated March 5, 2012. Accessed June 27, 2013.
Creutzfeldt-Jakob disease fact sheet. National Institute of Neurological Disorders and Stroke website. Available at: http://www.ninds.nih.gov/disorders/cjd/detail%5Fcjd.htm . Updated June 6, 2013. Accessed June 27, 2013.
Dawidowska K. Where’s the (safe) beef? Prevention . 2004;56:34.
Hill AF, Butterworth RJ, Joiner S, et al. Investigation of variant Creutzfeld-Jakob disease and other human prion diseases with tonsil biopsy samples. Lancet . 1999;353:1183-1189.
Holman RC, Belay ED, Christensen KY, et al. Human prion diseases in the United States. PLoS One . 2010;5(1):e8521.
Patry D, Curry B, Easton D, Mastrianni JA, Hogan DB. Creutzfeld-Jakob disease (CJD) after blood product transfusion from a donor with CJD. Neurology . 1998;50(6):1872-1873.
Rinne ML, McGinnis SM, Samuels MA, Katz JT, Loscalzo J. Clinical problem-solving. A startling decline. N Engl J Med . 2012;366(9):836-842
Moo-ve over, beef burgers: EN finds many alternatives. Environmental Nutrition . 2004;27:5.
Prusiner SB. Detecting mad cow disease. Scientific American . 2004;291:60-67.
Raloff J. Better protection from mad cow disease. Science News . 2004;165:93.
Smith-Bathgate B. Creutzfeldt-Jakob disease: diagnosis and nursing care issues. Nursing Times . 2005;101:52.
vCJD (Variant Creutzfeldt-Jakob disease). Centers for Disease Control and Prevention website. Available at: http://www.cdc.gov/ncidod/dvrd/vcjd/ . Updated August 23, 2010. Accessed June 27, 2013.
Variant Creutzfeldt-Jakob disease. World Health Organization website. Available at: http://www.who.int/mediacentre/factsheets/fs180/en/ . Updated February 2012. Accessed June 27, 2013.
Zeidler M, Sellar R, Collie DA, et al. The pulvinar sign on magnetic resonance imaging in variant Creutzfeldt-Jakob disease. Lancet . 2000;355:1412-1419.
- Reviewer: Rimas Lukas, MD; Brian Randall, MD
- Review Date: 06/2013
- Update Date: 05/11/2013